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George Frederick II the Elder (; April 5 1539 - April 25 1603) was Margrave of Ansbach and Bayreuth, as well as Regent of Prussia. He was the son of George, Margrave of Brandenburg-Ansbach and a member of the House of Hohenzollern.

George Frederick reigned in Ansbach and Jägerndorf since 1556 and, after the death of his cousin Albert Alcibiades in 1557, also in Bayreuth. He took over the administration of the Duchy of Prussia in 1577, when the then-reigning Duke Albert Frederick became ill.

He was the last of the older Franconia line of the House of Hohenzollern. Upon his death Ansbach and Bayreuth were inherited by younger princes of the Brandenburg line according to a domestic treaty in Gera from 1598.

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