* In 2008, Zach appeared in a series of web commercials for Absolut vodka, with their skits paying homage to the '80s show The Golden Girls.
* Galifianakis prefers mixing up the work that he does such as doing some stand-up comedy and making small films that he himself wrote.
* If he could produce his own music festival, Zach would want the following artists to perform: fellow North Carolinians The Annuals, Run DMC, Rufus Wainwright, and Will Oldham.
* He used to have a pet cat named Mr. Stevenson after the British singer-songwriter Cat Stevens.
* Into the Wild director Sean Penn got interested in casting Zach for the film after seeing him in Out Cold, a snowboarding movie Zach was in which Penn's son kept watching over and over.
* He owns a 60-acre farm in North Carolina which he dreams of converting into a writers' retreat. He spends some time there when he's not working in Los Angeles, California.
* His uncle Nick Galifianakis is a former member of the U.S. Congress and represented North Carolina from 1967-1973. He also went up against Jesse Helms for the Senate seat in 1972.
* In 2006, Zach released a single called "Come Over and Get It (Up in 'Dem Guts)", a comedic rap/hip-hop/dance song. * Galifianakis, who was a series regular as Davis on Tru Calling, said that he hated being on the show.
* Zach is of Greek descent and belongs to the Greek Orthodox faith.
* Zach made a short film with fellow comedian Brian Posehn.
* Zach is 5' 8" (1.73 m) tall. He has often been seen in his shows and movies with a full beard, which he named Shelly. [edi
* He is friends with comedian Patton Oswalt. Oswalt was the one who invited him to join The Comedians of Comedy tour, which helped Zach to be more recognized by the public.
* He can play the piano. Zach incorporates his musical talents in his stand-up comedy gigs.
* In February 2008, Zach joined Will Ferrell's Funny or Die college tour. He also once performed on a tour called the Comedians of Comedy.
* Zack is an admirer of famous political theorist Noam Chomsky. He also likes music artist Morrissey. 
* Apart from appearing in the Fiona Apple music video for "Not About Love", he shot a music video with him singing an Anita Baker song. He was also in Kanye West's "Can't Tell Me Nothing" video.
* His favorite movie is Garfield while one of Zach's favorite shows is All in the Family.