Less than a year after The Invisible Man Returns was released, this entry in the series was released. It is the one that seems to fit the least in the Invisible Man movie sequels. It couldn't be more different, and yet, Curt Siodmak contributed to the story of this one as well. There is hardly anything resembling a horror movie here. It is a sci-fi concept and there is a romance mixed in, but it is more of a screwball comedy than anything.
John Barrymore plays a funny old inventor who uses a chemical combined this time with an electrical contraption to turn people invisible. He won't use it on himself and so he puts out a classified ad for a volunteer. He gets Virginia Bruce as Kitty, who really only wants to teach her boss at the fashion house, where she models, a lesson. Howard is a rich guy funding the professor's experiments. He provides the obvious romantic interest for the invisible woman. Ruggles plays a butler who is overly excitable and does dozens of double takes and prat falls through the movie. Homolka plays a gangster (supposedly) from Mexico who wants to steal the professor's invention. His henchmen are Brophy, MacBride, and Shemp Howard. Yes, of course, that means even more slapstick routines. Margaret Hamilton, a year after The Wizard of Oz, plays the professor's frazzled assistant. She doesn't have much screen time and is only mediocre in a supporting role that is barely developed. So, there's no connection to the Griffin family in this one, and it turns out alcohol brings on the invisibility at the most opportune or inopportune moments. It is funny at times, but the ending jumps ahead with a punchline out of left field.