Katherine Heigl, best known for her current work on TV's "Grey's Anatomy," will step into Judd Apatow's "Knocked Up," replacing former leading lady Anne Hathaway, who bailed on the flick due to "creative differences."

Hollywood Reporter: "Katherine Heigl is set to star opposite Seth Rogen in Universal Pictures' "Knocked Up," Judd Apatow's follow-up to "The 40-Year-Old Virgin." Apatow, who wrote the script and is directing, produces with Shauna Robertson and Clayton Townsend. The story centers on the unexpected pregnancy and other consequences of a man's one-night stand. Heigl steps into the role vacated by Anne Hathaway, who left because of creative reasons."



Ms. Heigl has also appeared in "The Ringer," "Valentine," and a whole lot of other bad movies.