Sundance 2010: RT's 10 Most Anticipated Movies

We pick the handful of features you simply can't afford to miss.

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Splice

Splice - The ingenious, high-tech corporate conspiracy thriller Cypher didn't quite break director Vincenzo Natali into the mainstream, but the more explicitly horror-themed Splice -- showing in Sundance's genre-friendly Midnight strand -- might find him a welcoming cult audience. A cautionary tale set in the world of modern genetics, it stars Adrien Brody and Sarah Polley as a pair of scientists who play dangerous games with human and animal DNA. But though it features state of the art effects, the film has been hailed as a return to the bizarre, intelligent psychological sci-fi style pioneered by David Cronenberg in the 80s, most notably in his classic remake of The Fly.

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