"The Heart Of The Matter" is the fourth episode of the fourth season of Grey's Anatomy and the 65th produced episode of the series. It is also the 69th produced episode of the Grey's Anatomy franchise. It was broadcast on October 18, 2007.
In the wake of the breakdown of their marriage, Callie and Izzie face off while George is stunned when Callie agrees to forgive him while Izzie confides in Alex about her affair and get a very unexpected reaction. Derek propositions Meredith about their future together while Derek teaches Cristina a lesson when he notices her mistreatment of Lexie and her interns. Richard's neice returns to the hospital with Adele.
This episodes' title references the song The Heart Of The Matter, originally sung by Don Henley
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