Asylum is the 10th episode of Season 1. It aired on November 22, 2005.
Sam and Dean investigate a long-shuttered mental asylum that has the power to drive intruders mad and murderous.
At the deserted Roosevelt asylum, in Rockford, Illinois, police officers Walter Kelly and Danny Gunderson rouse some kids who have broken into the asylum. Afterwards Walter Kelly goes home and inexplicably shoot his wife and himself.
Sam has been checking up on their contacts - Caleb, Jefferson, Pastor Jim - to see if John has been in touch. While Sam and Dean argue about John's whereabouts, Dean receives a text message from him, containing coordinates. The boys travel to Rockford and speak to Danny Gunderson about his partner's death, who tells them that his partner chased the kids into the south wing of the asylum.
They find reference in John's journal to kids who disappeared from the south wing in 1972. After a brief visit to the asylum, Sam and Dean track down a psychiatrist, James Ellicott, whose father Sanford Ellicott was the Chief of Staff at the asylum. Sam poses as a patient, and finds out from Dr Ellicott that the south wing housed the criminally insane, and that in 1964 the patients rioted, killing Dr Ellicott, whose body was never found.
The boys return to the asylum, where they discover Kat, who has been separated from her boyfriend Gavin. She insists on helping the boys find Gavin, and she goes with Dean while Sam goes off on his own. Sam finds a terrified Gavin who says that a ghost kissed him and tried to whisper something to him.
Meanwhile Kat is trapped in a room with a ghost, and Dean is unable to open the door. When Sam arrives he works out that it's trying to communicate with her, not hurt her. It whispers "One thirty-seven" to her, before it leaves, which the boys deduce is a room number. While Dean goes to find the room, Sam tries to lead the kids out, but finds they are trapped. He leaves Kat with a shotgun to protect them, and responds to a phone call he thinks is from Dean. Sam doesn't find Dean, but is found by Dr. Ellicott, who uses his powers on Sam
Dean finds journals documenting Dr. Ellicott's cruel experiments designed to test his theories that provoking extreme anger in patients would be therapeutic. When he finds Sam has left Kat and Gavin to respond to the phone call, which Dean didn't make, Dean takes off to find him.
Dean finds Sam in the basement, and then locates a secret door which he thinks led to the hidden procedure room where the experiments were carried out. As he prepares to open it, Sam shoots him in the chest with rocksalt, blasting him through the fake wall. Standing over Dean, Sam expresses his rage at Dean, for thwarting his attempts to find John. Dean hands over his gun to Sam, who fires it repeatedly at Dean, only to find it is not loaded.
Dean overpowers Sam, and knocks him out. He searches the room and finds the corpse of Dr Ellicott, stuffed in a cabinet. As he prepares to salt and burn it, the ghost of Dr Ellicott appears and attacks Dean, until Dean manages to toss his Zippo onto the corpse. As it burns, the ghost disappears.
Sam recovers, and seems unaffected and the boys escort Kat and Gavin from the asylum.
The next morning, while the boys sleep, Dean's cell phone rings. Sam answers the phone - it's John.
"Hey You" by Bachman Turner Overdrive
Dean: I love the guy, but I swear he writes like friggin' Yoda.
Dean: I'm Nigel Tufnel, from the Chicago Tribune.
Dean: Let me know if you see any dead people, Haley Joel.
Dean: Hey, Sam, who do you think is a hotter psychic: Patricia Arquette, Jennifer Love Hewiit, or you?
Dean: "Who do you think is a hotter psychic: Patricia Arquette, Jennifer Love Hewitt or you?"
Sam: "You were running from what?" Gavin: "There was... There was this girl. Her-her-her face... It was all messed up." Sam: "Okay, okay. Listen, listen. This girl, did she try to hurt you?" Gavin: "What? No. She, uh..." Sam: "She what?" Gavin: "She kissed me." Sam: "Uh, uhm, but ... but she didn't hurt you physically?" Gavin: "Dude, she kissed me. I'm scarred for life." Sam: "Well, trust me, it could've been worse."
Kat: "So, how do you guys know about all this ghost stuff?" Sam: "It's kind of our job." Kat: "Why would anyone want a job like that?" Sam: "I had a crappy guidance counselor."
Dean: (after burning Sanford Ellicott's body) "You're not gonna try to kill me, are you?" Sam: "No." Dean: "Good. Because that would be awkward."