Alberto Estrella was born on September 23, 1962 in Mexico; his brother Rodrigo went on to become a notable doctor in Mexico. Alberto made his first television appearance at age 11 on the Mexican version of Sesame Street as a character named Abelardo Montoya. He was billed as Alberto Rodriguez Estrella in his first role as an adult, in the 1986 film El otro. Several different roles in movie shorts and brief television arcs followed before Estrella earned a supporting role in 1990's Los fugitivos, alongside Daniel Balk and Guillermo Capetillo.
Another notable role followed in the form of Guama Botero, one in a trio of brothers linked by blood and fate in the 1993 drama Principo y fin. The role earned him a Silver Ariel nomination for the Mejor Cactuacion Maculina (Best Supporting Actor) performance of the year. Roles followed over the next few years, including La reina de la noche (1994), En el sire (1995) and Salon Mexico (1996). Estrella then took the lead in the 2000 prison drama Tres reos, a performance which garnered critical acclaim. 2002's Pacas de a mil shined a light on Estrella once again. Later that same year, as Roberto in eXXXorcisms, Estrella delivered a powerhouse performance. Backed by a dense, heart-stopping plot delivered by writer/director Jaime Humberto Hermosillo, Estrella's turn was very well-received. The movie itself was nominated for four Ariel Awards, including Estrella's second nomination, and his first for a lead role.
Most of Estrella's recent notable roles have come on the small screen. Reinventing himself as a convincing telenovela antagonist, Estrella has starred as a villain on three different shows since his most recent Ariel nomination, initially in Entre el amor y el odio as Marcial Andrade. After roles in Contra viento y marea and Lo que la vida me robo, Estrella resurfaced in the role of Danilo Vargas on the popular telenovela La malquerida, which premiered in 2014. Other telenovelas which Estrella has contributed to include El Equipo and the 2013-14 hit show What Life Took From Me (in the role of Juventino). Estrella also had a minor role as Adjutant AFI in the 2004 Denzel Washington vehicle Man on Fire.