The older sister of actress Lillian Randolph, Amanda Randolph worked her way up the black vaudeville circuit as a singer and comedienne. She made her first screen appearance in the Vitaphone two-reeler The Black Network (1935) as the supposedly untalented wife of a radio sponsor; ironically, she sounded better than the film's official leading lady Nina Mae McKinney. After appearing in a handful of all-black feature films she established herself as a character actress on network radio. In the 1950s she was generally cast as maidservants in films, with the notable exception of her performance as Sidney Poitier's mother in 1950's No Way Out. On television, Amanda Randolph was seen to excellent advantage as the Kingfish's domineering mother-in-law on The Amos 'N' Andy Show (1951-1953) and as Louise the maid on Make Room for Daddy (1954-1964).