Poor Sidney Prescott. She's survived an entire franchise dedicated to her demise, and it really all came down to reasons that were far beyond her control. What's that saying about "the sins of the father" (or, in this case, mother)? Yeah, Sidney sort of represents the epitome of the adage.
Consider this: Sidney's own boyfriend, Billy, played the long con on her and ultimately tried to off her in the first Scream because Sidney's mom broke apart his parents' marriage -- yikes. But it gets worse: who should come around for revenge in Scream 2 but Billy's mom herself, understandably upset, along with an accomplice who just wanted to be famous for killing Sidney. Scream 3 sees Sidney terrorized by a half brother she never knew she had, upset about being rejected by their mother, and 4's Ghostface Killer turns out to be Sidney's own cousin, itching to get a taste of Sidney's fame. Sidney is safe and sound as of now, of course, but you never know; there might be a great granduncle or a step-niece just rarin' for a go at her.