Markie Post, Corbin Bernsen, and Kelsey Grammer headline this tightly wound thriller about a devoted wife who makes a shocking discovery about her successful and outwardly upstanding husband, a successful dentist. Inspired by a true story, Appointment for a Killing opens as Joyce Benderman (Post) basks in the glow of her recent good fortune. Raised in poverty, Joyce can't believe her luck when she is married to charismatic dentist Stan (Bernsen). Stan is everything a woman like Joyce could ever want; he's successful, handsome, and a good provider. But Stan has a dark side that's about to flip his wife's world upside down. When Joyce discovers that Stan is an adulterer, who thrives on sexually ensnaring and manipulating young, unsuspecting women, she begins to suspect that he may also be the culprit responsible for a recent series of heinous murders. At once terrified of her husband yet determined to stop him, Joyce agrees to aid a federal agent (Grammer) in tricking her husband into admitting his guilt. But this game is deadly serious, because should Joyce arouse her husband's suspicions odds are good that she'll become his next victim.