Ronald Coleman plays Arrowsmith here, and he's fine as he always seems to be. He plays the doctor from his just-out-of-college years, small town life, to his promotion to a research giant. Coleman also gets help from Helen Hayes who plays a nurse in the hospital, who, in the span of oh, 5 minutes, becomes his wife. Soon after arriving in the big city in the huge research laboratory (which, according to the set design, is right behind Dr. Caligari's) and he discovers a cure for bubonic plague! But he needs human subjects to test this out on, so he and Hayes pack everything and go to the most infected part of the world they can that is suffering from the disease, where they meet up with the wildly overacting (). But the disease is overwhelming and‚?¶ well, the results are what concludes this. I am not really too sure about the ending as well. What made Arrowsmith act the way he did? The movie somewhat drags a bit in the end, when they wind up on the West Indies, and the whole black spiritual singing in ALL of the scenes does get grating after a while. All in all, this is an OK movie, but not the best of Coleman, Hayes or John Ford.