David Cross, Patton Oswalt, Brian Poshen... they have all (deservedly) crossed over to the mainstream. Zach Galifianakis is well on his way. But it's not too late to start name dropping the likes of Maria Bamford and Eugene Mirman as people you were into before they were considered super cool. And they will be, oh yes, they will be. Patton and Eugene specifically will be the "aww, isn't there more?" portions of the show.
oh yeah, most of the other people are ok, too.