A mom of two, Irene (Vera Farmiga) has been addicted to cocaine for years. Her husband Steve (Clint Jordan) uses, but not nearly as much. When Irene tries to use her son's birthday check from Grandma to buy drugs, she knows it's time to check into rehab. She meets Bob (Hugh Dillon), a nurse in the rehab center who's been clean for five years, and they start to have an affair. Irene manages to get clean, but it's so fragile that the tiniest thing can plunge her right back into addiction, and does. This movie really brings home how easy it is to get caught up in that rat race and how incredibly hard it is to get off-and stay off. Vera Farmiga is great, as always. I thought it was very realistic and I liked the ending. I recommend Down to the Bone and give it an 85%.