Sarah (Tiffany Stinky) has a surprise and gruesome announcement for Muzzy (Billy Scam)...she has contracted a deadly virus called the ROT which she got by having sex with a dead guy from the local funeral home, and now she has passed it along to Muzzy. Slowly the two of them begin to ROT alive, spreading the insidious, flesh-melting disease to friends and foes and any unfortunate individual that comes in contact with them. But Sarah and Muzzy's problems don't end there. The man responsible for their living death and the horrifying epidemic is Dr. Robert Olsen (Joel D. Wynkoop) - a deranged scientist who used to work for the government's germ warfare research division. As the plague of rotting flesh accelerates out of control, the FBI and other secretive governmental agencies become involved, and things are about to get even messier.