Raja Gosnell Director Neil Patrick Harris Patrick Winslow Actor Brendan Gleeson Victor Doyle Actor Jayma Mays Grace Winslow Actor Sofía Vergara Odile Actor Hank Azaria Gargamel Actor Jacob Tremblay Blue Actor Nancy O'Dell Self Katy Perry Smurfette Voice Jonathan Winters Papa Voice Christina Ricci Vexy Voice J.B. Smoove Hackus Voice George Lopez Grouchy Voice Anton Yelchin Clumsy Voice John Oliver Vanity Voice Frank Welker Azrael Voice J. David Stem Screenwriter David N. Weiss Screenwriter Jay Scherick Screenwriter David Ronn Screenwriter Karey Kirkpatrick Screenwriter Jordan Kerner Producer Ezra Swerdlow Executive Producer Ben Haber Executive Producer Paul Neesan Executive Producer Phil Meheux Cinematographer Bill Boes Production Design Sabrina Plisco Film Editing Heitor Pereira Original Music David Rubin Casting Rita Ryack Costume Design Véronique Marchessault Costume Design Michele Laliberte Supervising Art Direction Vincent Gingras-Liberali Art Director David Gaucher Art Director Elise de Blois Set Decoration Marie-Soleil Denommé Set Decoration Frédérique Bolté Set Decoration