Adapted from a Zane Grey story, Wagon Wheels is a remake of the 1931 Gary Cooper starrer Fighting Caravans. Randolph Scott assumes Cooper's role, playing a trail guide named Clint Belmet. The plot follows the progress of a typical wagon train journey from Missouri to Oregon, with the usual quote of Indian attacks and outlaw treachery. Murdock (Monte Blue), the main villain, foments trouble between the whites and Indians on behalf of a carter of foreign fur traders, adding a bit of international intrigue to the proceeding. Gail Patrick, still in her "ingenue" period, portrays the heroine along more intelligent and self-reliant lines than usual. Generous amounts of stock footage from Fighting Caravans were liberally sprinkled throughout the 57-minute time span of Wagon Wheels.