Krystal lives out her dream of getting married and dedicating her life to two young sons, but the effects of growing up in a dysfunctional family, along with the death of her father, turn Krystal into an alcohol, heroin, meth and fentanyl addict.

Growing up, Peter excelled in everything he did, but the pressure of being perfect, coupled with a secret childhood trauma led Peter to fentanyl, and now he's smoking 1,000 times the lethal dose every day.

Jesse grows up gender fluid in a household rife with addiction, trauma and dysfunction; after nearly losing his mother to drugs, Jesse spirals into an addiction of his own and now lives on the streets.

Ashley was a straight-A student with dreams of attending university; her hopes were dashed when her stepfather introduced her to meth and heroin as a teenager.

After a terrifying burn accident as a child, Jayden grows up hoping to become a firefighter and fight California's notorious forest fires; after a series of tragic events, 20-year-old Jayden now smokes dangerous amounts of fentanyl.

Elliot overcame a traumatic childhood and moved to Las Vegas to pursue his dream of becoming a chef, but the rampant drug culture in restaurant kitchens along with the sudden death of his brother sent Elliot reeling.

When Ryan severely injured his ankle, doctors prescribed opioids; Ryan, couch-bound for a year, enjoyed the emotionally numbing effect of the drugs; now 26, he is addicted to fentanyl and has nearly lost his life to overdose multiple times.

When a family secret is accidentally revealed to Brea, the world she's known her entire life is shattered; as she begins to tailspin out of control with the help of alcohol and pharmaceuticals, all her mother can do is fight to pick up the pieces.