The Great Mutant Outbreak of 2017 caused creatures to grow to an incredible size and develop incredible intelligence, forcing humans to scatter for underground. After a giant mutant attack dumps her on the surface far away from her Terrarium home, Kipo gets a crash course on apocalyptic survival. She soon bands together with other surface dwellers -both human and mutant- on her journey to locate home, her father and the missing people of her underground city.