Dylan Walsh Dr. Sean McNamara Actor Julian McMahon Dr. Christian Troy Actor John Hensley Matt McNamara Actor Joely Richardson Julia McNamara Actor Valerie Cruz Grace Santiago Actor Sophia Bush Ridley Lange Guest Star Lindsay Hollister Nanette Babcock Guest Star Kate Mara Vanessa Bartholomew Guest Star Ruth Williamson Hedda Grubman Guest Star Edward Moss Mr. Diamond Guest Star Michael Raysses Mr. Ambrose Guest Star Roma Maffia Dr. Liz Cruz Guest Star Javier Calderon Esai Guest Star Gina Marie Fields Airport Security Guard Guest Star Eric Fleeks Officer Stone Guest Star Linda Klein Nurse Linda Guest Star