In the Season 3 premiere, the doctors of Chastain are surrounded by new rules and doctors, as Red Rock Mountain Medical takes over the hospital. Conrad finds himself in a dangerous situation when the construction for a new neurosurgery center causes a gas explosion at Chastain. Meanwhile, new hotshot neurosurgeon Barrett Cain is put to the test with a complicated surgery and Mina acts as a support for Nic, who is struggling with a devastating loss.

Cain tries to recruit Bell and Kit to join him on a dangerous surgery, with the intent of garnering publicity for the hospital. Meanwhile, the Raptor finds himself with an emotional attachment to a patient whose life is put in his hands, and Mina's friend, Adaku, arrives at the hospital with shocking news. Also, Devon rotates out of the ER and Nic plans a surprise for Conrad.

A police officer shows up to the ER with an injured criminal that he caught in the act, and it's up to the Chastain staff to keep him alive in order to save an innocent life. Nic gets roped into a surgical rotation with Cain that leaves her questioning the way he operates, and Conrad makes a shocking discovery about the hospital. Meanwhile, Bell pursues a new fiscal venture that may bring him into a whole new market.

Devon's patient, who was pronounced dead, suddenly revives. Conrad is left doubting Devon's judgement and wondering what happened. A well-known white supremacist falls under the care of Cain and Nic, causing the two to butt heads on how to move forward. Meanwhile, on their way to a medical convention, the Raptor and Mina get stuck in a strange town, where they uncover new information about Red Rock Medical.

After a plane crashes in Atlanta, Devon is overcome by guilt at the thought that he could have prevented the tragedy. Bell, who was a passenger on the plane, makes it his personal mission to save the life of the man seated next to him. Meanwhile, Adaku returns to ask Mina a big favor, the Raptor struggles with telling his birth parents about meeting his biological father and Conrad and Nic consider risking it all to investigate a drug that might be linked to Jessie's death.

On National Nurses' Day, Chastain's nurses are severely understaffed and overworked, leaving them all feeling exhausted and underappreciated. Cain performs a dangerous surgery on a new patient he won in a game of poker. Meanwhile, Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death, The Raptor comes face-to-face with his birth mother for the first time and Irving attempts to take the next step in his relationship with Jessica.

When one of Chastain's own is brought into the emergency room with life-threatening injuries, the staff rallies around each other to try to save her life, while disagreements over how to best handle her care put Cain at odds with the rest of the doctors. Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention. Meanwhile, Conrad turns heads when he shares data about Hemopleatin, and Kyle begins volunteering at the hospital.

Upon dubbing Thanksgiving "the most dangerous day of the year," Devon and Irving are inundated with patients in the ER. When an A-list celebrity enters the hospital after swallowing a wish bone, Logan Kim assigns a new surgeon to the case in the hopes of garnering extra publicity. Meanwhile, tensions run high at the Raptor home when he hosts his biological and adoptive families for a Thanksgiving dinner and Kyle interrupts Nic and Conrad's low-key plans.

Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. When Devon discovers that his VIP patient has a life-threatening brain condition, the doctors ban together to perform a risky surgery. Meanwhile, Mina discovers that Adaku has a dangerous heart condition that puts her and the baby at risk, and Kyle forms a personal relationship with a patient.