From the second the movie starts (with the creepy laughs and lalalas) it quickly establishes and unsettling mood and high tension, until it reaches its climax and then kinda drags on without knowing what to do for the last 20 minutes.
The film is amazing to look at, everyone involved is incredibly gorgeous and the locations are all fantastic, and the performances are pretty good, too, but it's hard to ''enjoy'' given how mysoginist it comes out. It's very interesting to explore relationships through sex, and how love can make a slave out of us all, but not when the film only gives women such a hard time about it.
Not to say it isn't serious, but cancer is something that becomes more and more common everyday, to the point that almost anyone has been neart it some time. ''50/50'' doesn't full-on go for laughs, but it does find a charming balance between the gutwrenching sadness and the sweetness of the people around you that cheer you up. Everyone in the cast deserves credit for their wonderful performances, and Will Reiser's script stupendous, human and real (not only do you identify yourself with these characters and this situation, there's also the reality of being based on Reiser's own experience).