Splice

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2:05

Splice

R

2010

1h 47m

Sci-Fi

Horror

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Tomatometer

Popcornmeter

75%

Tomatometer

200 Reviews

37%

Popcornmeter

250,000+ Ratings

Geneticists Clive (Adrien Brody) and Elsa (Sarah Polley) specialize in creating hybrids of species. When they propose the use of human DNA, their pharmaceutical company bosses forbid it, forcing them to conduct experiments in secret. The result is Dren, a creature with amazing intelligence and physical attributes. At first, Dren exceeds their wildest dreams, but as she begins to grow at an accelerated rate, she threatens to become their worst nightmare.

Critics Consensus

It doesn't take its terrific premise quite as far as it should, but Splice is a smart, well-acted treat for horror fans.

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Perri Nemiroff

Shockya.com

Aug 13, 2010

4/5

Fascinating and exciting yet disturbing and potentially upsetting.

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David Stratton

At the Movies (Australia)

Aug 11, 2010

3.5/5

I love the character of Dren, which is nerd spelt backwards. I loved the relationship between her and her putative parents: Adrian Brody and Sarah Polley.

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Kim Newman

Empire Magazine

Jul 22, 2010

4/5

It doesn't go the complete distance, but this is a wholly admirable, refreshingly grown-up science-fiction movie: a Frankenstein with a beating, gene-spliced heart and top-of-the-range performances.

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Matt Brunson

Film Frenzy

Jan 21, 2026

2.5/4

Splice is inventive enough that it’s a real shame when it falls apart heading into the home stretch.

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Gayle Sequeira

Inverse

Aug 26, 2025

The drama doesn’t stint on sci-fi weirdness, featuring sex-swapping creatures and an uncomfortable stretch of interspecies psychosexual tension. But for all its bizarro energy, it’s also surprisingly perceptive about what it takes to be a parent.

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Sarah Vincent

Sarah G Vincent Views

Jan 4, 2025

I cannot recommend Splice because while the concept is genuinely disturbing, it is mostly poorly executed so you may only get a hot fifteen minutes, and I am being generous, of visceral horror.

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revolver.0 8

@Revolver08 3 days ago

What starts as solid premise quickly evolve into b movie writing at the end

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Unjay M

@RT49070163 Sep 14, 2026

Adrienne Brody was charismatic but flawed. Let’s just say Delphine Chaneac really transformed herself…. It’s relevant in that we are at the point where science has raced so far ahead of ethics- we can do so much but should we? Splice takes the Frankenstein story and brings it convincingly and unnervingly into the present day. Interesting and disturbing, sometimes beautiful in the most disturbing ways possible.

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Robert P

@Superbad Sep 11, 2026

Splice = a *2.5* star Movie

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B P

@Bradster69 Sep 6, 2026

Not Bad, but Not My Favorite

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Gaia N

@Bleepbloop Jan 21, 2026

The definition of "oh dear, well that aged poorly". An interesting if unsettlingly awkward cultural artifact, we'll leave it at that.

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Richard L

@KaneLives Nov 30, 2025

Disregarding the unnecessary 'boss fight' at the end, Splice is a creative and engaging contemplation on the morals of cloning and scientific progress in general, providing an odd but impressive mix of cuteness and warmth, and the straight-up disturbing. It gets points for not pulling any punches, but it's also unfortunate that it didn't go the extra mile narratively.

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Vincenzo Natali

Director

Adrien Brody

Clive

Sarah Polley

Elsa

Delphine Chaneac

Dren

Simona Maicanescu

Joan Chorot

David Hewlett

Barlow

Subject Two

55%

47%

Subject Two

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Species

42%

31%

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Synopsis

Geneticists Clive (Adrien Brody) and Elsa (Sarah Polley) specialize in creating hybrids of species. When they propose the use of human DNA, their pharmaceutical company bosses forbid it, forcing them to conduct experiments in secret. The result is Dren, a creature with amazing intelligence and physical attributes. At first, Dren exceeds their wildest dreams, but as she begins to grow at an accelerated rate, she threatens to become their worst nightmare.

Director: Vincenzo Natali
Producer: Steven Hoban
Screenwriter: Vincenzo Natali, Antoinette Terry Bryant, Doug Taylor
Distributor: Warner Bros. Pictures
Production Co: Gaumont
Rating: R (Language|Disturbing Elements|Nudity|Sci-Fi Violence|Strong Sexuality)
Genre: Sci-Fi, Horror
Original Language: English
Release Date (Theaters): Jun 4, 2010, Wide
Release Date (Streaming): May 19, 2016
Box Office (Gross USA): $17.0M
Runtime: 1h 47m
Sound Mix: Dolby Digital

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