Oliver Stone Director, Screenwriter Colin Farrell Alexander Actor Angelina Jolie Olympias Actor Val Kilmer Philip Actor Christopher Plummer Aristotle Actor Jared Leto Hephaestion Actor Rosario Dawson Roxane Actor Anthony Hopkins Old Ptolemy Actor Brian Blessed Wrestling Trainer Actor Tim Pigott-Smith Omen Reader Actor Connor Paolo Young Alexander Actor Gary Stretch Cleitus Actor John Kavanagh Parmenion Actor Nick Dunning Attalus Actor Marie Meyer Eurydice Actor Elliot Cowan Ptolemy Actor Joseph Morgan Philotas Actor Ian Beattie Antigonus Actor Denis Conway Nearchus Actor Neil Jackson Perdiccas Actor Rory McCann Crateros Actor Raz Degan Darius III Actor Annelise Hesme Stateira Actor Féodor Atkine Roxane's Father Actor Jonathan Rhys-Meyers Cassander Actor Garrett Lombard Leonnatus Actor Christopher Kyle Screenwriter Laeta Kalogridis Screenwriter Matthias Deyle Executive Producer Pierre Grunstein Executive Producer Moritz Borman Producer Jon Kilik Producer Rodrigo Prieto Cinematographer Alex Marquez Film Editing Yann Hervé Film Editing Jan Roelfs Production Design Jim Erickson Set Decoration