Harry Bradbeer Director Millie Bobby Brown Enola Holmes Actor, Producer Sam Claflin Mycroft Holmes Actor Henry Cavill Sherlock Holmes Actor Helena Bonham Carter Mrs. Holmes Actor Fiona Shaw Miss Harrison Actor Adeel Akhtar Inspector Lestrade Actor Frances de la Tour Tewksbury, The Dowager Actor Louis Partridge Lord Tewksbury Actor Jack Thorne Screenwriter Paige Brown Producer Alex Garcia Producer Ali Mendes Producer Mary Parent Producer Adam Bosman Film Editing Daniel Pemberton Original Music Michael Carlin Production Design Martin Hitchcock Art Director Lisa Chugg Set Decoration Consolata Boyle Costume Design Jina Jay Casting