Raja Gosnell Director Hank Azaria Gargamel Actor Neil Patrick Harris Patrick Winslow Actor Jayma Mays Grace Winslow Actor Sofía Vergara Odile Actor Tim Gunn Henri Actor Jonathan Winters Papa Voice Alan Cumming Gutsy Voice Katy Perry Smurfette Voice Fred Armisen Brainy Voice George Lopez Grouchy Voice Anton Yelchin Clumsy Voice Kenan Thompson Greedy Voice Jeff Foxworthy Handy Voice John Oliver Vanity Voice Wolfgang Puck Chef Voice Gary Basaraba Hefty Voice Paul Reubens Jokey Voice B.J. Novak Baker Voice Frank Welker Azrael Voice J. David Stem Screenwriter David N. Weiss Screenwriter Jay Scherick Screenwriter David Ronn Screenwriter Jordan Kerner Producer Ezra Swerdlow Executive Producer Ben Haber Executive Producer Paul Neesan Executive Producer Phil Meheux Cinematographer Bill Boes Production Design Sabrina Plisco Film Editing David Rubin Casting Richard Hicks Casting Rita Ryack Costume Design Heitor Pereira Original Music Chris Shriver Art Director Regina Graves Set Decoration