Annie Potts Mary Elizabeth "M.E." O'Brien Sims Actor Lorraine Toussaint Rene Jackson Actor Mae Middleton Mary Elizabeth Actor Shari Dyon Perry Rene Actor Chris Mulkey Colliar Sims Actor Dan Byrd Young Colliar Actor John Lafayette James Jackson Actor Donzaleigh Abernathy Sara Jackson Actor Olivia Friedman Kelly Sims Williams Actor Christopher Winsor Davis Sims Actor Nancy McLoughlin Guest Star William Converse-Roberts Guest Star Millie Perkins Guest Star Richard Biggs Guest Star Shandra Olds-Whitlow Guest Star