Dr. Will Halstead (Nick Gehlfuss) has to balance the stress as the ER's supervising Attending Physician while exploring a budding romance with Dr. Natalie Manning (Torrey DeVitto), emergency pediatrics resident. Rising star heart surgeon Dr. Connor Rhodes' (Colin Donnell) skills are put to the test with the arrival of a new, highly competitive Cardiothoracic Fellow, Dr. Ava Bekker (Norma Kuhling). Dr. Daniel Charles (Oliver Platt) recovers from both the physical and psychological injuries from being shot, but still remains the Sherlock Holmes of psychiatry. Dr. Sarah Reese (Rachel DiPillo) continues her psychiatry residency under Dr. Charles, despite new reservations in the wake of her mentor's assault. Former Navy flight surgeon Dr. Ethan Choi (Brian Tee) brings his battlefield skills to the front lines of Chicago's busiest ER, the go-to place for victim's of the city's gun violence. Sharon Goodwin (S. Epatha Merkerson), the venerable head of Chicago Med, balances the pressure of keeping the city's largest hospital afloat while maintaining an atmosphere of quality care and compassion.