Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Gina Gershon Elana March Guest Star Ophelia Lovibond Kitty Winter Guest Star Raza Jaffrey Andrew Paek Guest Star Brennan Brown Kevin Elspeth Guest Star Kate Hodge Karen Lutz Guest Star Michael Louis Gibson Detective Palmer Guest Star Ed Moran Detective Guest Star Anthony Arkin Client Guest Star Joanna Rhinehart Ms. Bracken Guest Star McKinley Belcher III Reeling Detective Guest Star Robert Doherty Executive Producer, Writer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer, Writer John Polson Director