New York doctor Zoe Hart (Rachel Bilson) has reached a crossroads in her life when she decides to accept an offer from a stranger to work with him at his practice in Alabama. When she arrives in town, she discovers that the man has died and left her his half of the practice in his will, something that doesn't exactly make her new partner happy. Despite the shock of Southern life and some less-than-hospitable town folk, Zoe decides to give her new life a chance and discovers a new side of herself in the process.