Damon Wayans Roger Murtaugh Actor Seann William Scott Wesley Cole Actor Kevin Rahm Captain Brooks Avery Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Maggie Lawson Natalie Guest Star Jonathan Sadowski Andrew Guest Star Annet Mahendru Lena, Layla Guest Star Richard Whiten Chief Flores Guest Star Juan Javier Cardenas Hector Guest Star Robin Thomas Victor Halderman Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer