Blake Lively Serena van der Woodsen Actor Leighton Meester Blair Waldorf Actor Penn Badgley Dan Humphrey Actor Chace Crawford Nate Archibald Actor Ed Westwick Chuck Bass Actor Kaylee Defer Charlie Rhodes Actor Kelly Rutherford Lily van der Woodsen Actor Matthew Settle Rufus Humphrey Actor Barry Watson Guest Star Margaret Colin Guest Star Andrea Gabriel Guest Star Michelle Trachtenberg Guest Star Robert John Burke Guest Star William Baldwin Guest Star Sofia Black-D'Elia Guest Star Josh Schwartz Executive Producer, Writer Stephanie Savage Executive Producer Leslie Morgenstein Executive Producer Bob Levy Executive Producer Joshua Safran Executive Producer Joe Lazarov Design Mark Piznarski Director Matt Whitney Director Anna Mastro Director Dan Steele Writer Amy Heckerling Director John Stephens Director Sara Goodman Writer Natalie Krinsky Writer Norman Buckley Director Jake Coburn Director Andy Wolk Writer Annemarie Navar-Gill Writer Jessica Queller Writer