Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor, Director Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Desmond Harrington Michael Actor Christian Borle David Horowitz Guest Star Melissa De Sousa Luz Horowitz Guest Star Babak Tafti Jonathan Dawson Guest Star Matthew Montelongo Armored Truck Driver Guest Star Olli Haaskivi Terry Weaver Guest Star Tom Everett Scott Henry Baskerville Guest Star Margaret Odette Debora Garissi Guest Star Neal Gupta Tony Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer, Writer Brandon Tanori Writer