Goran Visnjic Dr. Luka Kovac Actor Maura Tierney Abby Lockhart Actor Mekhi Phifer Dr. Gregory Pratt Actor Parminder Nagra Dr. Neela Rasgotra Actor Linda Cardellini Nurse Samantha Taggart Actor Shane West Actor Scott Grimes Dr. Archie Morris Actor Laura Innes Dr. Kerry Weaver Actor John Stamos Dr. Tony Gates Actor Forest Whitaker Curtis Ames Guest Star Keith David Pastor Watkins Guest Star Leland Orser Dr. Lucien Dubenko Guest Star Busy Philipps Hope Bobeck Guest Star Shawn Hatosy Willis Peyton Guest Star Michelle Hurd Courtney Brown Guest Star J.P. Manoux Dr. Dustin Crenshaw Guest Star Charlayne Woodard Angela Gilliam Guest Star Malaya Rivera Drew Katey Alvaro Guest Star Laura Cerón Nurse Chuny Marquez Guest Star Christopher Chulack Executive Producer Michael Crichton Executive Producer David Zabel Executive Producer John Wells Executive Producer R. Scott Gemmill Executive Producer