Rachel Bilson Dr. Zoe Hart Actor Jaime King Lemon Breeland Actor Wilson Bethel Wade Kinsella Actor Cress Williams Lavon Hayes Actor Scott Porter George Tucker Actor Tim Matheson Dr. Brick Breeland Guest Star McKaley Miller Rose Hattenbarger Guest Star Rosalie Ward Betty Breeland Guest Star Nancy Travis Emmeline Hattenbarger Guest Star Kaitlyn Black AnnaBeth Guest Star Armelia McQueen Shula Whitaker Guest Star Reginald VelJohnson Dash DeWitt Guest Star Dawn Didawick Old Lady 1 Guest Star Esther Scott Old Lady 2 Guest Star Mary Gross Old Lady 3 Guest Star Drew Koles Frederick Dean Guest Star Deborah S. Craig Shelley Ng Guest Star Ross Philips Tom Long Guest Star Leila Gerstein Executive Producer Josh Schwartz Executive Producer Stephanie Savage Executive Producer Len Goldstein Executive Producer Jason Ensler Executive Producer