Chuck Lorre Creator, Executive Producer, Writer Johnny Galecki Leonard Hofstadter Actor Jim Parsons Sheldon Cooper Actor Kaley Cuoco Penny Actor Simon Helberg Howard Wolowitz Actor Kunal Nayyar Raj Koothrappali Actor Mayim Bialik Amy Farrah Fowler Actor Melissa Rauch Bernadette Rostenkowski Actor Kevin Sussman Stuart Guest Star Christine Baranski Beverly Guest Star Kathy Bates Mrs. Fowler Guest Star Joshua Malina President Siebert Guest Star Sean Astin Dr. Pemberton Guest Star Keith Carradine Wyatt Guest Star Teller Mr. Fowler Guest Star Brian Posehn Bert Guest Star Kal Penn Dr. Campbell Guest Star Rati Gupta Anu Guest Star Lauren Lapkus Denise Guest Star Lindsey Kraft Marissa Guest Star David Theune Dr. Graybel Guest Star Bill Prady Executive Producer, Writer Steven Molaro Executive Producer, Writer Eric Kaplan Writer Tara Hernandez Writer Adam Faberman Writer Alex Yonks Writer Steve Holland Writer David Goetsch Writer Maria Ferrari Writer Jeremy Howe Writer Andrew Gordon Writer Anthony Del Broccolo Writer Mark Cendrowski Director Kristy Cecil Director Nicole Lorre Director