A young girl learns a difficult lesson about the bonds of family in this drama based on the novel for young adults by Kimberly Willis Holt. Tiger Ann Parker (Kelsey Keel) is a girl growing up in the small rural community of Saitter, LA, and she's not especially happy with her life. Her mother (Amelia Campbell) suffered brain damage after a childhood accident that significantly reduced her IQ, and her father (Chris Owens) is "slow" and has trouble reading and writing, which has made Tiger Ann the subject of a lot of cruel taunting from her classmates at school. When Tiger Ann's Aunt Dorie (Juliette Lewis) offers to let her stay with her in the "big city" of Baton Rouge, the young girl is eager to see what the world has to offer beyond the city limits of Saitter. But Tiger Ann soon discovers that leaving her home and family behind is not as simple as she imagined. My Louisiana Sky also features Shirley Knight; actor Adam Arkin directed, in what was his first feature-length project.