Kathy Bates Iris Actor Sarah Paulson Hypodermic Sally Actor Evan Peters James March Actor Wes Bentley Detective John Lowe Actor Matt Bomer Donovan Actor Chloë Sevigny Dr. Alex Lowe Actor Denis O'Hare Liz Taylor Actor Cheyenne Jackson Will Drake Actor Angela Bassett Ramona Royale Actor Lady Gaga The Countess Actor Mare Winningham Hazel Evers Guest Star Finn Wittrock Tristan Duffy Guest Star Christine Estabrook Marcy Guest Star Max Greenfield Gabriel Guest Star Lily Rabe Aileen Wuornos Guest Star Naomi Campbell Claudia Guest Star Richard T. Jones Detective Andy Hahn Guest Star Alexandra Daddario Natacha Rambova Guest Star John Carroll Lynch John Wayne Gacy Guest Star Shree Crooks Scarlett Lowe Guest Star Ryan Murphy Executive Producer Brad Falchuk Executive Producer Tim Minear Executive Producer Bradley Buecker Executive Producer Jennifer Salt Executive Producer James Wong Executive Producer Alexis Martin Woodall Executive Producer