Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Amra Silajdzic Sass Dumonde Guest Star Ricardo Molina Christopher Garcia Guest Star Escher Holloway Torrey Powell Guest Star Tanner Maguire Boy Guest Star Tyler Jacob Moore U.S. Marine Guest Star Billy Brown Business Pedestrain Guest Star Karina D'Bautista Lab Tech Guest Star Gerald Downey Prof. William Aldicott Guest Star Julie McKinnon A , V Lab Tech Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Trey Callaway Writer Eric Laneuville Director