Paul Weitz Director Robert De Niro Jack Byrnes Actor, Producer Ben Stiller Greg Focker Actor Owen Wilson Kevin Rawley Actor Dustin Hoffman Bernie Focker Actor Barbra Streisand Roz Focker Actor Blythe Danner Dina Byrnes Actor Teri Polo Pam Focker Actor Jessica Alba Andi Garcia Actor Laura Dern Prudence Actor Harvey Keitel Randy Weir Actor Kevin Hart Nurse Louis Actor Daisy Tahan Samantha Focker Actor Colin Baiocchi Henry Focker Actor Tom McCarthy Dr. Bob Actor Yul Vazquez Junior Actor Jack Axelrod Chappy Actor John Hamburg Screenwriter, Producer Larry Stuckey Screenwriter Jane Rosenthal Producer Jay Roach Producer Nancy Tenenbaum Executive Producer Daniel Lupi Executive Producer Meghan Lyvers Executive Producer Andrew Miano Executive Producer Ryan Kavanaugh Executive Producer Remi Adefarasin Cinematographer Greg Hayden Film Editing Leslie Jones Film Editing Myron I. Kerstein Film Editing Stephen Trask Original Music William Arnold Production Design Sue Chan Supervising Art Direction Thomas T. Taylor Art Director David Smith Set Decoration Molly Maginnis Costume Design Joseph Middleton Casting