Stephen Collins Rev. Eric Camden Actor Catherine Hicks Annie Jackson Camden Actor David Gallagher Simon Camden Actor Beverley Mitchell Lucy Camden Actor Mackenzie Rosman Ruthie Camden Actor George Stults Kevin Kinkork Actor Geoff Stults Ben Kinkirk Actor Rachel Blanchard Roxanne Richardson Actor Nikolas Brino David Camden Actor Lorenzo Brino Sam Camden Actor Ashlee Simpson-Ross Cecilia Smith Actor Jeremy London Chandler Hampton Actor Barry Watson Matt Camden Guest Star Jessica Biel Mary Camden Guest Star Tara Lipinski Christine Guest Star Dan Lauria Andrew Hampton Guest Star Sarah Danielle Madison Sarah Glass Camden Guest Star Orson Bean Patient , Mr. Hampton Impersonator Guest Star Flavia Costa Nurse Guest Star Alan Fudge Lou Dalton Guest Star Hiram Kasten Pharmacist Guest Star Scotty Leavenworth Peter Petrowski Guest Star Keith MacKechnie Matt's Boss Guest Star Kyle Richards Matt's Patient Guest Star Marcia Wallace Nurse Guest Star Aaron Spelling Executive Producer E. Duke Vincent Executive Producer Brenda Hampton Executive Producer, Writer Tony Mordente Director Chris Olsen Writer Jeff Olsen Writer