Annie Potts Mary Elizabeth "M.E." O'Brien Sims Actor Mae Middleton Mary Elizabeth Actor Lorraine Toussaint Rene Jackson Actor Shari Dyon Perry Rene Actor Chris Mulkey Colliar Sims Actor Olivia Friedman Kelly Sims Williams Actor John Lafayette James Jackson Actor Donzaleigh Abernathy Sara Jackson Actor Don McManus Guest Star Randall Slavin Guest Star Richard Biggs Guest Star Derrex Brady Guest Star Andrew McFarlane Guest Star Venus DeMilo Guest Star