Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Jane Adams Dr. Mel Karnofsky Guest Star Rob Leo Roy Phil Guest Star John Farley Records Clerk Guest Star Mary Jo Smith Nurse Guest Star Chariesse La Velle News Anchor Guest Star Susan Merson Woman In Cafe Guest Star Lauren Cohn Orderly Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Christopher Lloyd Executive Producer Joe Keenan Executive Producer Robert H. Egan Director Rob Hanning Writer