Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Rene Auberjonois Professor William Tewksbury Guest Star Tom McGowan Kenny Daly Guest Star Randall Rapstine Sheldon Hastings Guest Star Michael Shepperd Merrill George Guest Star Devika Parikh Emcee Guest Star Edward Hibbert Gil Chesterton Guest Star Neil Simon Andy Guest Voice David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer, Director Mark Reisman Executive Producer Dan O'Shannon Executive Producer, Writer Jon Sherman Writer