Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Robin Pearson Rose Guest Star Josh Stamberg Guest Star Sarah Utterback Guest Star Kate Burton Guest Star Moe Irvin Guest Star Steven W. Bailey Guest Star Jack Merrill Guest Star John O'Brien Guest Star Kathleen M. Darcy Guest Star Wally Rudolph Guest Star Noelle McCutchen Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Jim Parriott Executive Producer, Writer Harry Werksman Writer Kip Koenig Writer Krista Vernoff Writer Mimi Schmir Writer Ann Hamilton Writer Peter Horton Director John David Coles Director Gabrielle G. Stanton Writer Sarah Pia Anderson Director Darnell Martin Director Scott Brazil Director Tony Goldwyn Director Wendey Stanzler Director