Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Edward Herrmann Guest Star Caroline Aaron Guest Star Eve Gordon Guest Star Amy Hill Guest Star Debra Christofferson Guest Star Jack Axelrod Guest Star Martin Spanjers Guest Star Moe Irvin Guest Star Ray Ford Guest Star Linda Eve Miller Guest Star Candice Afia Guest Star Amrapali Ambegaokar Guest Star Tymberlee Hill Guest Star Gloria Garayua Guest Star Richard Keith Guest Star Molly Kidder Guest Star Joy Osmanski Guest Star Mark Saul Guest Star Joseph Williamson Guest Star Winston Story Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Mark Wilding Writer Daniel Minahan Director