David Kohan Creator, Executive Producer Max Mutchnick Creator, Executive Producer Eric McCormack Will Truman Actor Debra Messing Grace Adler Actor Sean Hayes Jack McFarland Actor Megan Mullally Karen Walker Actor Barry Manilow Himself Guest Star Debbie Reynolds Bobbi Adler Guest Star Sara Gilbert Cheryl Guest Star Chris Penn Rudy Guest Star Jackie Geary Cashier Guest Star Peggy Lane O'Rourke Woman in Sub Shop Guest Star Gary Riotto Waiter Guest Star Adrian Mojica Security Guard Guest Star James Burrows Executive Producer, Director Jeff Greenstein Executive Producer Kari Lizer Writer Alex Herschlag Executive Producer Jhoni Marchinko Executive Producer