Lawrence Guterman Director Jeff Goldblum Professor Brody Actor Elizabeth Perkins Carolyn Brody Actor Miriam Margolyes Sophie the Castle Maid Actor Alexander Pollock Scott Brody Actor Tobey Maguire Lou Voice Alec Baldwin Butch Voice Sean Hayes Mr. Tinkles Voice Susan Sarandon Ivy Voice Joe Pantoliano Peek Voice Michael Clarke Duncan Sam Voice Jon Lovitz Calico Voice Charlton Heston Mastiff Voice Salome Jens Collie at HQ Actor Glenn Ficarra Russian Blue Actor, Writer Danny Mann Ninja cat Voice Billy West Ninja cat Actor Andrew Lazar Producer Warren Zide Producer Christopher DeFaria Producer Craig Perry Producer Chris Bender Executive Producer J.C. Spink Executive Producer Bruce Berman Executive Producer John Requa Writer John Debney Original Music Michael A. Stevenson Film Editing Rick W. Finney Film Editing Jim Bissell Production Design Julio Macat Cinematographer Ed Jones Visual Effects Supervisor Boone Narr Stunt Coordinator