Tim Burton Director Paul Reubens Pee-wee Herman Actor, Producer E.G. Daily Dottie Actor Mark Holton Francis Actor Diane Salinger Simone Actor Tony Bill Terry Hawthorne Actor Cassandra Peterson Biker Mama Actor James Brolin Himself - as PeeWee Actor Morgan Fairchild Self Jan Hooks Tina Actor Judd Omen Mickey Actor Monte Landis Mario Actor Daryl Keith Roach Chuck Actor Starletta DuPois Sgt. Hunter Actor Professor Toru Tanaka Butler Actor Ed Herlihy Mr. Buxton Actor Ralph Seymour Francis' Accomplice Actor Lou Cutell Amazing Larry Actor Erica Yohn Madam Ruby Actor Jason Hervey Kevin Morton Actor John Paragon Movie Lot Actor Actor William E. McEuen Executive Producer Richard Abramson Producer Robert Shapiro Producer Danny Elfman Original Music Philip Giffin Original Music Victor J. Kemper Cinematographer Billy Weber Film Editing Wallis Nicita Casting David L. Snyder Production Design Thomas L. Roysden Set Decoration Robert P. Cohen First Assistant Director Phil Hartman Screenwriter Michael Varhol Screenwriter