John Doman Rodrigo Brogia, Alexander VI Actor Mark Ryder Cesare Borgia Actor Diarmuid Noyes Alessandro Farnese Actor Marta Gastini Giulia Farnese Actor Isolda Dychauk Lucrezia Borgia Actor Stanley Weber Juan Borgia Actor Udo Kier Pope Innocent VIII Actor Andrea Sawatzki Adriana de Mila Actor Rudolf Martin Francheschetto Cibo Actor Assumpta Serna Vannozza Cattanei Actor Christian McKay Ascanio Sforza Actor Scott William Winters Raffaele Riario-Sansoni Actor Dejan Cukic Cardinal Giuliano della Rovere Actor Paul Brennen Agapito Geraldini Actor Metin Hüseyin Director Christoph Schrewe Director Dearbhla Walsh Director Oliver Hirschbiegel Director Thomas Vincent Director Athina Rachel Tsangari Director Tom Fontana Writer Brant Englestein Writer Kyle Bradstreet Writer Kevin Deiboldt Writer Frank Pugliese Writer Andrea Ciannavei Writer Sean Whitesell Writer Bradford Winters Writer Chris Albers Writer Audrey Fouché Writer Susanna Styron Writer Gina Gionfriddo Writer Thomas Kelly Writer James Yoshimura Writer Will Soodik Writer Marie Roussin Writer Larry J. Cohen Writer